Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2 Research Published on 2022-08-182022-10-05 Journal: Nature Medicine [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Administered administration Antiviral applicability approach conserved Critical disease drugs genetic change Genome greater hamster highlight IAV identify Immunity implication in vitro in vivo influenza A virus isolates mice Mutation nucleic acid predicted Prophylactic Prophylaxis provided retained RNA RNA secondary structure RNA structure SARS-CoV-2 secondary structure survival the SARS-CoV-2 therapeutic targeting therapy Transmission Vaccine variant viral genome Viral RNA virus [DOI] 10.1038/s41591-022-01908-x [Article Type] Research
Recent advances in RNA structuromeReview Published on 2022-07-012023-07-09 Journal: Science China. Life sciences [Category] COVID19(2023년), [키워드] 3D structure Decoding function Genome-wide high-throughput techniques. RNA secondary structure RNA structurome SARS-CoV-2 [DOI] 10.1007/s11427-021-2116-2 PMC 바로가기 [Article Type] Review
RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cellsRNA 편집은 인간 숙주 세포에서 SARS-CoV-2의 뉴클레오티드 다양성을 증가시킵니다Article Published on 2022-03-302022-09-11 Journal: PLoS Genetics [Category] SARS, 유전자 메커니즘, [키워드] binding affinity bioinformatic analysis Bronchoalveolar lavage fluid Characteristics Clustering COVID-19 pandemic COVID-19 patients COVID-19 research Critical enrichment Evolution of SARS-CoV-2 human host cell human host cells human lung cells implication increase Local mechanism metatranscriptomic nucleotide Phylogenetic analysis positive-sense predicted responsible RNA RNA modification RNA secondary structure RNA virus robust SARS-CoV-2 secondary structure single-stranded RNA virus Vaccine development virus [DOI] 10.1371/journal.pgen.1010130 PMC 바로가기 [Article Type] Article
Secondary Structure of Influenza A Virus Genomic Segment 8 RNA Folded in a Cellular EnvironmentArticle Published on 2022-02-232023-06-08 Journal: International Journal of Molecular Sciences [Category] 신종인플루엔자, [키워드] IAV influenza A virus RNA chemical mapping RNA secondary structure RNA virus [DOI] 10.3390/ijms23052452 PMC 바로가기 [Article Type] Article
Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effectorAcademicSubjects/SCI00010 Published on 2021-12-162022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, SARS, [키워드] activated activating Activation amplification binding complex CRISPR degrade dependent on detect DNA DNase domain ENCODE extrinsic generate guide RNA Immunity in vivo lack limit of detection locus Nuclease nucleic acid nucleotide position plate reader resulting RNA RNA secondary structure robust sensitivity sequence specificity stimulate subunit the SARS-CoV-2 virus Type type III variety Vibrio [DOI] 10.1093/nar/gkab1190 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
LinearTurboFold: Linear-time global prediction of conserved structures for RNA homologs with applications to SARS-CoV-2408 Published on 2021-12-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Algorithm Antisense oligonucleotides conserved conserved structures coronavirus Coronaviruses COVID-19 Critical diagnostic diagnostics disease drugs Effectiveness effort experimental work faster full-length full-length genome functions Genome genomes guide RNAs help homolog homologous folding homologs identify in silico Interaction knowledge Local magnitude Pandemics predict Primers reduce Region RNA RNA secondary structure RNA structure RNA virus RNA virus RNA viruses RT-PCR SARS-CoV-2 sequence Significance siRNAs structural alignment Structural analysis Structure structures target therapeutic UTRs Vaccine variant variants viral genomes whole genome [DOI] 10.1073/pnas.2116269118 PMC 바로가기 [Article Type] 408
In vivo structure and dynamics of the SARS-CoV-2 RNA genomeArticle Published on 2021-09-282022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 치료제, [키워드] 3′-UTR 5′-UTR addition Analysis Antiviral strategies canonical Cell conformation develop discontinuous transcription domain Evidence facilitate functional Genome genome organization help in vivo Intensive Interaction Local Regulating Regulation Replication reveal RNA RNA genome RNA secondary structure SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA sequences Structure the SARS-CoV-2 Transcription translation translational viral life cycle viral replication virions weakened [DOI] 10.1038/s41467-021-25999-1 PMC 바로가기 [Article Type] Article
Clinico-Genomic Analysis Reveals Mutations Associated with COVID-19 Disease Severity: Possible Modulation by RNA StructureArticle Published on 2021-08-312022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome alteration analyzed association Asymptomatic Clinical outcome clinical phenotype clinical phenotypes Clinical presentations clinico-genomic co-morbidities co-morbidity Cohort Combination coronavirus correlated COVID-19 disease severity examined genetic component genomic help highlight identify individual Integrative analysis Mild moderate Mortality Mutation N protein outcome pandemic progresses patients protein level Respiratory Support RNA RNA secondary structure RNA structure SARS-CoV-2 SARS-CoV-2 genome severity significantly Spread Structure Support Surveillance the disease the SARS-CoV-2 genome Treatment understanding variants of concern viral infection with COVID-19 [DOI] 10.3390/pathogens10091109 PMC 바로가기 [Article Type] Article
Extensive C->U transition biases in the genomes of a wide range of mammalian RNA viruses; potential associations with transcriptional mutations, damage- or host-mediated editing of viral RNAResearch Article Published on 2021-06-012022-10-29 Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS, [키워드] accounted adaptive aligned ANOVA antiretroviral APOBEC association Caliciviridae change coding region Combination component contribute Coronaviridae dataset disease driven by Evidence Evolution Extensive fixation Flaviviridae Frequency Generation time genetic change Genome genome sequence genomes genomic HCV HIV-1 homoplasy identity infecting investigated mammalian mammals mechanism mechanisms multivariable analysis Mutation mutations Neutral Occurrence parameter phylogenetically provide random replicate Replication reported representing retrovirus RNA RNA secondary structure RNA virus RNA viruses SARS Coronavirus SARS-CoV-2 sequence sequence variability significantly subset Substitution thought transcriptional upstream Viral RNA virus virus while [DOI] 10.1371/journal.ppat.1009596 PMC 바로가기 [Article Type] Research Article
Developing effective siRNAs to reduce the expression of key viral genes of COVID-19COVID-19의 주요 바이러스 유전자 발현을 감소시키는 효과적인 siRNA 개발Research Paper Published on 2021-04-102022-09-10 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 변종, 치료법, [키워드] 24 hours antiviral drug antiviral drugs binding efficiency can be used clinical development Consensus COVID-19 COVID-19 pandemic degrade develop Developing effective Efficiency effort Endothelial cell endothelial cells expression gene silencing human lung medication membrane nucleocapsid overexpressing PBE Probability provide reduce reducing Region RNA RNA molecules RNA secondary structure SARS-CoV-2 secondary structure secondary structures significantly siRNA siRNAs suggested target gene Target genes the disease Vaccine Viral viral gene viral genes viral genome viral infection [DOI] 10.7150/ijbs.59151 PMC 바로가기 [Article Type] Research Paper